The Powerpuff Girls were my superheroes in high school. Ask any of my friends and they would tell you how I always say Buttercup is my spirit animal because she's so fierce and tough. Now they might not look like it but The Powerpuff Girls have just turned 20! Cartoon Network’s all-time favorite series follows the life of three super-cute, but super-fierce little girls made from sugar, spice, and everything nice – with a splash of Chemical X.